Okay, all you Princesses. Gabapenten works on RLS for me - my Neurologist says it's one of the few drugs with no top limit. Doing 3 @ of 300mg caps at night, a fourth if that isn't enough. How much of my RLS is due to Peripheral Neuropathy? They are definitely related. If you have the type of PN where you get burning of nerves in calf/foot (I describe it as an electric current, but the Med Profession doesn't allow those words), then that and Lamotrigine work. Exercise helps; so does the Compression Socks (from Duluth Trading - those Dr. Scholls are too painful) for me. I've had too damn many years to experiment with that stuff and compare notes with support group. Neither Neurologist nor Urologist nor GIM want me using Lyrica - and i don't like the list of significant side-effects (You know: the ones with high percentages, not just-one-out-of-750-people), or the interaction problems.
Obviously, Lyrica works for some. Just watch your symptoms and make sure of no interactions.
Isn't Gabapenten an anti-spasmodic? Whichever is, using for RLS may be off-Rx (You know, not what it is normally prescribed for), but my Doc isn't the only one.
Quinine used to be used, but Feds nix-ed it - dose has to be too high and becomes unsafe, so don't bother to drink Tonic Water! And I like Gin & Tonic. Nuts.