I use Diclofenac gel, otherwise know as Voltaren, for nerve pain due to Peripheral Neuropathy in legs & feet, now spreading to hands. It comes as a pill, too, but the cream works locally, and doesn't put hardly any in your blood.
I call it a miracle drug, and thus I don't have to use an opiate. The strength I use is prescription, and it used to be prescription only, but I now see it on the OTC shelves at lower percentage. It deals with pain, not sure what effect it might have on "tender" areas or open wounds. It doesn't burn on regular skin. Diclofenac is a NSAID, like Ibuprofen/Asprin. It isn't a barrier cream. ASK the Doctor, FIRST!
Anyone, what about a water-soluable gel for slickness, instead of vasolene? You know, the kind used on a condom or to take a baby's temperature anally. Those also aren't barrier creams. Vasoline is probably a barrier, but is petroleum based, I think.
By the way, Tylenol does absolute nothing for me, but Ibuprophen does. Wouldn't you know it? My cardiologist forbids it 'cause it is a blood thinner and I'm taking a strong prescription one of those, daily, for a different condition
Good luck.